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IntroductionHormones are organic substances that are secreted by plants and animals and that function in the regulation of physiological activities and in maintaining homeostasis. They carry out their functions by evoking responses from specific organs or tissues that are adapted to react to minute quantities of them. The classical view of hormones is that they are transmitted to their targets in the bloodstream after discharge from the glands that secrete them. This mode of discharge (directly into the bloodstream) is called endocrine secretion. The meaning of the term hormone has been extended beyond the original definition of a blood-borne secretion, however, to include similar regulatory substances that are distributed by diffusion across cell membranes instead of by a blood system. . Among animals, the hormones of the vertebrates--particularly those of humans and other mammals--are the best known. Most vertebrate hormones originate in specialized tissues, called endocrine tissues, and are carried to their targets through the bloodstream. Endocrine glands.A major endocrine gland in vertebrates is the pituitary, which consists of two distinct sections: the anterior pituitary (or adenohypophysis) and the posterior pituitary (or neurohypophysis). The anterior pituitary is sometimes called the master gland, because it secretes several hormones that affect the other endocrine glands. For example, the anterior pituitary hormones thyrotropin and adrenocorticotropic hormone (ACTH) regulate endocrine activity in the thyroid and the outer region (cortex) of the adrenal glands, respectively. The anterior pituitary also secretes hormones that affect the sex glands. One of these is follicle-stimulating hormone (FSH), which stimulates egg production in the ovaries and sperm production in the testes. Another is luteinizing hormone (LH). In females, LH works in conjunction with FSH to regulate the female reproductive cycle and the secretion of female sex hormones. In males, LH controls the production of the male sex hormones. Other hormones produced in the anterior pituitary include growth hormone, which is responsible for normal body growth, and prolactin, which promotes milk production in female mammals. Its designation as the master gland notwithstanding, the anterior pituitary itself is regulated by substances called releasing hormones that are secreted by the hypothalamus, the part of the brain located directly above the pituitary. These hypothalamic hormones stimulate--or, in some cases, inhibit--the secretions of the anterior pituitary. The posterior pituitary stores and releases two hormones: oxytocin, which causes the uterus to contract during birth, and vasopressin, which acts on the kidneys to restrict the output of urine. These two hormones are actually produced by the hypothalamus, which is linked directly to the posterior pituitary. Other endocrine glands in vertebrates include the thyroid, parathyroids, adrenals, pancreas, and gonads (sex glands). The thyroid produces hormones that control metabolic rate and oxygen consumption. Hormones from the parathyroids are concerned with calcium concentration in the blood, and the pancreas releases insulin and glucagon, hormones that, respectively, lower and raise the blood-sugar level. Hormones from the adrenal cortex regulate glucose and sodium metabolism. Those secreted by the central portion (medulla) of the adrenals affect the heart and the circulatory and respiratory systems; these hormones are important in helping an individual cope with stress. The heart itself releases a hormone-- atrial natriuretic peptide--that helps regulate blood pressure, blood volume, and the salt and water balance within the blood. (see also Index: thyroid hormone, parathormone) The female sex hormones--the estrogens and progesterone--are produced by the ovaries. Together with FSH and LH, these hormones control the cyclical changes in the female reproductive system--the menstrual cycle in human females and the estrous cycle in other female mammals. The estrogens also are responsible for female sexual characteristics. Progesterone is concerned with the maintenance of pregnancy. Male sex hormones--known as androgens--include testosterone, which is secreted by the testes. Testosterone is responsible for the maintenance of male sexual characteristics. Hormone chemistry.Structurally, vertebrate hormones fall into two main classes. Those of the adrenal cortex and the sex organs are steroids, a major class of lipid compounds. Virtually all other known vertebrate hormones consist of amino acids. Most nonsteroidal hormones are composed of chains of amino acids--either short chains (polypeptides) or long chains (proteins). The hormones of the adrenal medulla, however, are composed of amino acid derivatives called amines, those of the thyroid of a single amino acid combined with atoms of iodine. It is believed that hormones achieve their effects on target tissues and organs through either of two mechanisms. The steroid hormones and the hormones of the thyroid can, as a result of their chemical structures, pass through cell membranes. These hormones apparently enter a target cell and combine with an intracellular receptor protein. The hormone-receptor complex then enters the cell's nucleus, where it apparently affects the activity of specific genes. Genes carry the cell's hereditary blueprint for protein synthesis, and so the interaction of the hormone-receptor complex with the genes influences the cell's production of proteins. Because many proteins function as enzymes within the cell, this influence on protein synthesis can have far-reaching effects on the cell's activities. The polypeptide, protein, and amine hormones are believed to operate by a different mechanism. These hormones do not enter the target cell; instead, they combine with a receptor protein on the cell's outer membrane. This hormone-receptor complex apparently triggers an enzyme in the membrane, causing the synthesis of a so-called second-messenger compound within the cell. This second messenger--in many cases, cyclic adenosine monophosphate (cyclic AMP)--apparently activates enzyme systems that bring about the desired action by the cell. It is interesting to note that both proposed mechanisms of hormone action involve the binding of the hormone to a specific receptor molecule. This feature accounts for the specificity of hormones; a hormone can have an effect only on cells that possess the appropriate receptor. Hormones probably exist in all invertebrates. In insects, neurosecretory cells in the brain produce thoracotropic hormone. This hormone stimulates glands in the thorax to secrete the hormone ecdysone, which causes the periodic molting, or shedding, of the hard exoskeleton. Another insect hormone, called juvenile hormone, maintains the larval state. A decrease in juvenile hormone triggers the development of the adult characteristics. Plants also have a hormonal system, which includes auxins, gibberellins, and cytokinins, all of which promote growth. Plant hormones also include several growth inhibitors, which regulate such activities as the fall of deciduous leaves in autumn and the development of dormancy in buds and seeds.
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